STUDY OF HORMONAL CHANGES AND LIPID PROFILE OF IRAQI WOMEN PRE-MENOPAUSE AND POST-MENOPAUSE

Abstract

Menopause is a normal part of aging for women and marks the end of their capacity to procreate, which is manifested by the cessation of periodic ovarian function and periodic menstruation. In this study, 25 postmenopausal women and 25 premenopausal women were selected within the age group that is fertile. The study measured Estrogen, Thyroid hormones (T3, T4, and TSH), and lipid profile [Total cholesterol (TC) and Triglycerides (TG)] in the blood serum of several Iraqi women both prior and post menopause, and compared the associated parameters. A negative and significant correlation was seen between total EST, age, T3, and T4. EST and cholesterol were positively and statistically significantly correlated. The study also showed statistically significant total T3, T4, and TSH between groups, were greater in premenopausal women compared to postmenopausal women, and showed lower blood estrogen values in women who have gone through menopause as opposed to those who have not. The study also showed that postmenopausal women have remarkably high concentrations of cholesterol and triglycerides, compared to women suffering from menstruation, and sensitivity analysis indicated that age is a potentially effective biomarker of menopausal effects, supplementing the sensitivity to cholesterol and triglycerides. These disorders are observed in the picture of the thyroid gland in postmenopausal women. Thus, they should be monitored at regular intervals to reduce thyroid dysfunction. Given the findings of recent studies and the analysis of earlier findings, there may be a problem with thyroid hormone activity as people age. In addition, the study showed a change in the profile of lipids in the blood in postmenopausal women. In premenopausal women, estrogen might be the protective factor. As a result, all postmenopausal women require a fat profile analysis and specialized health education.