EVALUATION OF INSULIN RESISTANCE IN PERIMENOPAUSAL WOMEN

Abstract

Background: Estrogen is an important female hormone that affect many metabolic process and it’s deficiency can lead to many problems not only regarding reproductive function but also other organs and systems in the body. Insulin is the major anabolic hormone responsible for glucose and energy homeostasis. Any defect in insulin function will result in insulin resistance that will lead to diabetes mellitus eventually. Aim of the study: To detect insulin resistance in perimenopausal women and investigate the effect of estrogen hormone and BMI on insulin resistance. Material and method: This cross-sectional study involved 38 women aged 30 – 51 years. All participants were in their second to fifth day of the menstrual cycle. They were instructed to fast for at least 8 hours before blood sample collection. The selected sample were carefully assessed to eliminate any possible factors that could affect the results of the study. Insulin resistance was measured using HOMA-IR method and values of more than two were considered insulin resistance. SPSS version 26 was used to statistically analyze the data. Results: The study yield non-significant negative correlation between estrogen level and insulin resistance. Significant positive correlation between BMI and insulin resistance. Conclusion: insulin resistance is higher in women with lower estrogen levels could suggest estrogen as protective factor against insulin resistance.