EVALUATION OF THE MORPHOLOGICAL STATE OF THE PANCREAS IN DIABETES IN CHRONIC POISONING WITH PESTICIDES
Keywords:
Chronic hyperglycemia, hallmark of diabetes mellitus (DM), endocrine disruption, oxidative stress, inflammation, diabetes mellitus, hyaline degeneration, inflammatory infiltrationAbstract
In this article, the opinions of our country's and foreign scientists are mentioned about the assessment of the morphological state of the pancreas in chronic poisoning with pesticides in diabetes mellitus. The evaluation of the morphological state of the pancreas in diabetes under chronic pesticide poisoning involves studying how long-term exposure to pesticides affects pancreatic tissue, particularly in individuals with diabetes. Chronic pesticide exposure has been shown to have detrimental effects on various organs, including the pancreas. In diabetes, the pancreas already undergoes significant morphological changes, particularly involving beta-cell dysfunction and loss. When combined with chronic poisoning by pesticides, the damage to the pancreas can be exacerbated, leading to altered endocrine and exocrine function.
References
1. Garcia-Arevalo M, et al. "Organophosphate pesticide exposure induces insulin resistance, disrupts glucose metabolism, and causes pancreatic beta-cell dysfunction." Toxicology Letters, 2014.
2. King H, Rewers M. "Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults." Diabetes Care, 1993.
3. Saxena P, et al. "Chronic pesticide exposure and pancreatic toxicity: Role of oxidative stress and inflammation." Journal of Endocrinology, 2010.
4. Atkinson MA, Eisenbarth GS. "Type 1 diabetes: new perspectives on disease pathogenesis and treatment." Lancet, 2001.
5. Lenzen S. "The mechanisms of alloxan- and streptozotocin-induced diabetes." Diabetologia, 2008.
6. Joshi SC, Sharma P, Sharma N. Pesticides and pancreatic toxicity: A review. Indian J Pharmacol. 2011.
7. Al-Eryani L, Wahlang B, Falkner KC, et al. Pesticides induce pancreatic dysfunction: A role for environmental toxicants in diabetes. PLoS ONE. 2015.
8. Heindel JJ, Blumberg B, Cave M, et al. Metabolism disrupting chemicals and metabolic disorders. Reprod Toxicol. 2017.
9. Moreno JA, Peinado FM, Barbancho M, et al. Chronic exposure to organophosphates induces morphological changes in the pancreas. Toxicol Appl Pharmacol. 2018.
10. Hectors TL, Vanparys C, Van Der Ven K, et al. Environmental pollutants and type 2 diabetes: A review of mechanisms that can disrupt beta-cell function. Diabetologia. 2011.
