CONTRAST-INDUSED NEPHROPATY

Abstract

All over the world, including in Uzbekistan, coronary heart disease is becoming an increasingly pressing medical and social problem [2]. Today, CHD is one of the most common causes of disability and mortality throughout the world [4]. Considering this fact, the fastest possible determination of patient management tactics is required already at the emergency room stage [5]. Heart and vascular diseases are the leading cause of mortality in industrialized countries [1]. For adequate assessment, treatment and prevention of cardiovascular diseases, high-quality and accurate diagnostics, including visualization of the heart and blood vessels, are of great importance. Intravenous or intraarterial administration of radiocontrast agents allows you to accurately determine the anatomy of blood vessels, the nature and location of lesions in them, and evaluate the characteristics of the blood supply to various organs and tissues. Without such information, modern treatment would simply be impossible. Selective angiography and computed tomography with the introduction of contrast agents are used everywhere in practical medicine. Therefore, safety issues for a study or intervention using KB become important. Despite the significant progress made in the development of KBs, they have a number of adverse effects, incl. nephrotoxicity. Prevention of nephrotoxic effects of KB, so-called. contrast-induced nephropathy remains an urgent problem, since it is known that CIN is often a harbinger of chronic renal failure, which worsens the prognosis [6]. Active use of X-ray computed tomography with intravenous administration of KB at the diagnostic stage increases not only the total radiation dose, but also nephrotoxicity.