ASSESSMENT OF INTRACARDIAC HEMODYNAMICS AND ELECTROLYTE BALANCE IN VARIOUS HEMODYNAMIC TYPES OF CHRONIC HEART FAILURE ACCOMPANIED BY

Abstract

Markers of renal fibrosis were evaluated in dynamics in order to study specific changes in the kidneys of patients with various hemodynamic types and functional classes of chronic heart failure with anemia and to evaluate the effectiveness of treatment with the drug exex. It was found that the marker of renal fibrosis TGF-β1 is 2591.0±108.4 and 755.0±18.87 PG/ml, respectively (p0,01), when the indicators of chronic heart failure in the blood were without anemia and anemia. This was evidenced by the process of fibrosis that occurred in the kidneys. After complex treatment with the addition of iron preparation, the TGF-β1 index decreased by 2.25 times (p0.01), the clinical condition, quality of life and indicators of resistance to physical exertion significantly changed in a positive direction. 120 patients with chronic heart failure who participated in the study were divided into 2 groups (75 of them had anemia and 45 of them had anemia) and passed excellent clinical and laboratory tests. To fulfill the tasks assigned to us, 75 patients with CHF were divided into 3 groups (in each group, more than 25 of them were stored in the left ventricular blood ejection fraction, intermediate and low were formed). The results confirmed that galectin-3 and TGF-β1, which indicate the processes of fibrosis in the heart and kidneys, as well as aldosterone, which is considered a marker of fibrosis in both organs, increase in parallel when chronic heart failure is accompanied by anemia.