GENOME-SEQUENCE IRAQI PATHOGENIC AVIAN INFLUENZA AVIRUS ANALYSIS

Abstract

Avian influenza was a zoonotic disease, has caused several epidemics in domestic fowl, Avian influenza may be contracted by several species, such as birds, animals, including humans, starlings, cats, and dogs. Poultry, such as chickens, turkeys, ducks, waders, beach birds, and ratites, are also vulnerable to the illness. Avian influenza results in significant financial losses in chicken populations. Influenza prevention The varying degrees of pathogenicity shown by viruses in various avian species, together with the diversity in viral features such as antigens and genes, provide challenges in accurately diagnosing viral infections in poultry or wild birds. This is because viruses may cause disease in several bird species. More precisely, this applies to the very contagious avian influenza viruses H5 and H7, which are now spreading. Aims of the study are; know the Inflammatory pathways activated during AIV infection by q-PCR for INFG and IL-4 Proinflammatory Mediators H5 and Positive H7 samples were sequenced for H5 and H7 genes and a phylogenetic tree was built. RT- PCR INFG + IL-4 Proinflammatory Mediaor are carried out must comprehend how the host immune system reacts to AIVs and ratio nally design new immunotherapies and vaccines. H5N1 the serotype isolate in these study has high genetic similarity isolates genotypes H5 in nearby countries in chicken/Iran, Sweden, Romania, Nigeria, swan Pakistan and in duck of Korea. The serotype H7N1 isolate in these study smiler to genetic viruses H7 isolated in chicken in Italy, Sweden and England. q-PCR results show LI4 and INFG were upregulated from lung and treachea of positive samples The result of this study reveal that H5N1 and H7N1 are the common serotypes in these area and development of vaccine to control infection are strongly recommended. This should be done by isolation of the infected virus of the above strains and according to the authority’s guidance.