THE IMPORTANCE OF IMPROVING THE DISTURBED INTESTINAL MICROFLORA IN THE PROGNOSIS OF NONSTEROIDAL ULCERATIVE COLITIS

Abstract

The article presents an analysis of the brief literature on the occurrence, main symptoms and treatment measures of nonsteroidal ulcerative colitis, which is considered a serious problem in gastroenterological practice. Today, a number of successes have been achieved in the diagnosis of nonsteroidal ulcerative colitis, as well as methods of conservative and surgical treatment are being improved. It is worth noting that the occurrence of pathological processes occurring in the intestine and the role of intestinal microflora in the treatment of these processes is invaluable. improving the microflora in the intestine leads not only to the relief of the symptoms of the disease and medical practice, but also can prevent the occurrence and recurrence of this pathology. Thus, the intestinal microflora are components that are important for performing the unofficial function of the intestine and preventing pathological processes, as well as for faster recovery from diseases. Changes in the luminal BA pool composition are caused by impaired microbiota enzymatic activity, which is seen in dysbiosis associated with inflammatory bowel disease. The anti-inflammatory effects of certain BA species on gut epithelial cells can be neutralized by altered BA transformation in the gut lumen, which may also contribute to the chronic inflammation loop associated with IBD.