ASSESSMENT OF CYTOKINE STATUS IN PREMATURE NEWBORNS WITH PERINATAL PATHOLOGIES
Abstract
Cytokines play a leading role in the pathogenesis, clinical course and outcome of hypoxic and infectious diseases of newborns. They are an important informative indicator of the state of the child's immune system during the adaptation period and ensure the interconnection of various body systems [3].
Some cytokines are contained in the blood in extremely low concentrations, accumulating mainly in the focus of inflammation, in addition, the biological activity of cytokines can be masked by binding them to inhibitor molecules circulating in the blood[2].
References
1. Navruzova Sh.I., Mukhamedova Sh.T. Tsitokin profile of newborns with systemic inflammatory response syndrome // Journal of theoretical and clinical medicine. –– 2018. - №4.– P.28-31.
2. Oradova A.Sh., Ustenova G.O., Stabaeva G.S. Methods of research of cytokines // Medicine. - 2014. –№4. - P.84-87.
3. Simbirtsev A.S. Tsitokiny: classification and biological functions. // Cytokines and inflammation. - 2004. Volume 3. - № 2. - P. 16-23.
4. Tabolin V.A., Degtyareva M.V., Polyakova O.V. // 9th Congress of Pediatricians of Russia “Children's Healthcare in Russia: Development Strategies.” - M., 2001. –C. 560.
5. Мухамедова Ш.Т. Особенности динамики цитокинов у новорожденных с синдромом системного воспалительного ответа. -M.: Бухара,2020. – 54 ст
6. Navruzova Sh. I., Muxamedova Sh. T. Prognostic Criteria of Severity of Systemic Inflammatory Response Syndrome in Newborns // American Journal of Medicine and Medical Sciences.- 2020. 10(2): -Р. 81-85.
7. Abdurakhmanov M., Inoyatov A. Sh., Sharopov S., Azimov M. The condition of immune system of infants with congenital cleft lip and palate.// Medical and Health Science Journal Czech Republik. - 2016. - V. 10. - Р. 23-29.
8. Саъдуллоева И.К., Ахмедов А.Т. Особенности состояния иммунитета детей с врожденным дефектом межжелудочковой перегородки сердца // Сборник научных трудов 76-я итоговая студенческая научно-практическая конференция. Красноярск.- 2012.- С. 520-521.
9. Sadulloeva I.K. Characteristics of immune system and functions of endocrine secretion in children with congenital heart disease after surgical correction // Ёш олимлар Республика илмий-амалий анжумани илмий ишлар тўплами. Термиз.- 2017.- С. 135-136.