BIOCHEMICAL CHANGES IN AMNIOTIC FLUID AFTER MATERNAL COVID-19
Keywords:
COVID-19, pregnancy, amniotic fluid, biochemical markers, phosphatidylcholine, sphingomyelin, fetal lung maturity, placental stress, neonatal outcomesAbstract
The COVID-19 pandemic has profoundly affected maternal and fetal health, especially in pregnant women. This study examines specific and non-specific biochemical indicators in the amniotic fluid of pregnant women who contracted COVID-19. Despite increasing information, few studies examine the correlation between these markers and fetal development, especially regarding lung maturity and placental function. To address this disparity, we performed a biochemical examination of amniotic fluid obtained from 70 pregnant women categorized into three groups: those with healthy pregnancies and those with COVID-19 throughout the second and third trimesters. Metabolites including phosphatidylcholine, sphingomyelin, total protein, and alpha-amylase were quantified utilizing high-performance liquid chromatography and biochemical analyzers. The findings indicated markedly reduced levels of phosphatidylcholine, sphingomyelin, and protein markers in women with COVID-19 relative to the control group. These reductions signify fetal lung immaturity and possible impairments in placental and hepatic function. Increased alkaline phosphatase levels indicated potential cellular injury. These discoveries underscore the necessity for focused monitoring and interventions during pregnancies impacted by COVID-19 to reduce hazards to fetal development. This study highlights the significance of comprehending the biochemical milieu of amniotic fluid following COVID-19 and its ramifications for neonatal outcomes, facilitating enhanced maternal and fetal care measures in pandemic contexts.
References
1. Mahase, E. (2022). COVID-19 and pregnancy outcomes: Review of evidence. BMJ.
2. Smith, R., & Johnson, A. (2021). Biochemical markers in amniotic fluid and fetal health. Journal of Obstetrics and Gynaecology.
3. Jabborov U. (2022). COVID-19's effect on amniotic fluid composition. Uzbek Medical Journal.
4. Brown, A., et al. (2020). Placental function in SARS-CoV-2-affected pregnancies. Placenta.
5. Jones, D., & Kim, H. (2022). Alterations in fetal biochemical markers during COVID-19. Clinical Chemistry.
6. Ahmedov S. (2021). Maternal infections and fetal outcomes in Central Asia. Asian Journal of Medical Sciences.
7. Miller, K., et al. (2020). Fetal development amid maternal infections. Fetal Medicine Today.
8. Kim, H., & Lee, S. (2021). Lipid metabolism and fetal lung development. Pediatrics.
9. Wilson, P., et al. (2022). Obstetric interventions during COVID-19: Impacts on outcomes. International Journal of Obstetrics.
10. Ahmedov S., & Jabborov, U. (2022). COVID-19 and pregnancy outcomes in Uzbekistan. Uzbek Medical Research Journal.
11. WHO. (2021). COVID-19 guidance for maternal health. World Health Organization Publications.
12. Liao, J., et al. (2022). Impact of SARS-CoV-2 on placental inflammation. Nature Communications.
13. Aliyev T., & Zubair, S. (2021). Role of amniotic fluid markers in fetal health. Journal of Perinatal Medicine.
14. Gupta, A., et al. (2021). COVID-19 and its effect on neonatal health. Lancet Child & Adolescent Health.
15. Yuldashev R., et al. (2022). Biochemical markers for assessing fetal development in Uzbekistan. Regional Medical Journal.
16. UNICEF Uzbekistan. (2022). Maternal and child health during COVID-19. UNICEF Publications.
17. Alizadeh, M., & Saleh, S. (2020). Biochemical implications of viral infections in pregnancy. Virology Journal.
18. Miller, J., et al. (2021). The interplay between maternal COVID-19 and fetal health. Journal of Maternal-Fetal & Neonatal Medicine.
