EXAMINATION OF THYROID FUNCTION AND SEMEN QUALITY IN INFERTILE MALES IN THI-QAR GOVERNORATE
Keywords:
Asthenozoospermia, Oligo-asthenozoospermia, TSH, Semen qualityAbstract
Introduction: Since thyroid hormones have been shown to have an effect on the development of germ cells and the quality of sperm, multiple components have been associated with the quality of sperm. This investigation studied the association between sperm traits and thyroid hormones in different age groups, and the association between TSH and specific sperm traits and the thyroid hormones T3 and T4.
Methods: This investigation utilized a prospective cohort approach and included 90 infertile men and age-matched healthy controls. The test subjects were divided into three groups of 30 men each: (A) comprised of men with asthenozoospermia, (B) comprised of men with oligozoospermia, and (C) comprised of healthy men. Thyroid hormones that are stimulating the thyroid (TSH), triiodothyronine (T3), and tetraiodothyronine (T4) were measured in the semen, and the properties of the semen, including volume, sperm density, mobility, and shape, were assessed in order to determine the quality of the semen.
Results: The results demonstrated that the total volume of group B was significantly greater than the total volume of group C, and the total volume of group A was significantly smaller than the total volume of group C. The concentration of sperm, the movement of sperm, and the percentage of sperm with a normal morphology in group A and group B were all significantly lower than in the healthy group. Additionally, the results demonstrated that the concentrations of TSH, total T3, and total T4 were significantly greater in the two groups of infertile men compared to the healthy individual. The infertile men and healthy men were segregated into three classes with the same age-G1: 20-29, 30-39, and 40-49. Additionally, they were categorized by the abnormality of sperm - asthenozoospermia and oligozoospermia. These findings suggest that all groups exhibited a pattern of increasing TSH, T3, and T4 levels with increasing age. As a result, low sperm quality and thyroid issues may be attributed to age. Men with abnormal sperm traits had a significantly higher concentration of TSH, total T3, and total T4. Specifically, individuals with asthenozoospermia and oligoasthenozoospermia had higher concentrations of thyroid hormones than controls. This implies that there may be a link between abnormal sperm traits and impaired thyroid function.
Conclusion: In this research found significantly elevated serum levels of TSH, T3, and T4 in infertile men compared to healthy controls. Furthermore, in both patient groups, TSH, T3, and T4 levels were observed to rise with age, in contrast to the healthy control group. These results suggest that both aging and thyroid disorders could negatively impact sperm volume, density, motility, and morphology.
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