THE USE OF COMBINED DECONTAMINATION AND NEUROPROTECTION IN THE TREATMENT OF SEPSIS IN CHILDREN OF THE FIRST YEAR OF LIFE

Abstract

Global statistics indicate that sepsis is marked by a severe clinical course, involving the development of a systemic inflammatory response syndrome (SIRS) with multi-organ failure, particularly affecting infants, thus diminishing their quality of life and posing a significant medical and social challenge. It is imperative to reconsider conventional perspectives on various aspects of pediatric and surgical sepsis, especially concerning etiopathogenetic approaches to treatment and the management of the rehabilitation phase. Therapeutic interventions targeting the normalization of intestinal microflora composition, prevention of excessive antigenic burden on the immune system, and correction of endotoxemia through the binding of toxic substances, including bacterial toxins and their metabolites within the intestinal lumen, are pathogenetically justified in the treatment of sepsis in infants during their first year of life.