THE USE OF ZIRCONIUM COMPOUNDS IN RADIOPHARMACY AND NUCLEAR MEDICINE

Abstract

Zirconium (Zr): It is a transition metal characterized by its silvery gray color. It is a type of flexible, moldable element. It is also included in the composition of many stable compounds. Zirconium is characterized by its high resistance to corrosion. Zirconium and its alloys have been used for centuries in a variety of applications. It is commonly used in corrosive environments, as zirconium alloys can be found in pipes, Chemicool website. Zirconium is aalso fittings, and heat exchangers, according to the used in steel alloys, colored glass, bricks, and ceramics. Abrasives, light bulbs, lamp filaments and gemstones, Synthetic, and some deodorants. Growing interest in using the radioactive isotope of zirconium, zirconium- 89 , for technology, Medical diagnosis by positron emission tomography (PET). This has stimulated significant research into the aqueous chemistry of zirconium with the design of new ligands to achieve the stability required for use in in vivo imaging. This review describes, Educational chemistry that supports the development of new Zr-based imaging agents and also includes related topics such as the synthesis of the radioactive isotope zirconium -89. Principles of PET and the use of monoclonal antibodies (mAbs) The review covers the period from the first reports of the clinical use of zirconium-89 in PET in 2006 to 2017 and is illustrated with examples of the use of radioisotopes. Mainly zirconium 89. In combination with mAbs for PET imaging in both, Preclinical and clinical studies. The standard unit for radioactivity is the Becquerel (Bq), It is necessary to determine the amount of radioactivity present in a medical imaging preparation Using a specific activity This is the measured activity (Bq) in the total amount of the compound, In the preparation of a radioactive compound, there are often unclassified compounds, and in this case the term “specific activity” is used, which is clearly visible and requires a technical technique. Analytical to determine the quantities of classified and unclassified compounds.