SYNTHESIS AND CHARACTERIZATION AND BIOLOGICAL STUDY OF SOME CYCLOHEXENONE DERIVATAVES FROM 2-ACETYL PYROL

Abstract

The research includes the preparation of various α-β unsaturated compounds by reacting 2-acetylpyrrole with different aromatic benzaldehyde substituents (S1-S5) and by reacting the compounds (S1-S5) with ethyl acetoacetate in a basic medium of 10% NaOH. A hexagonal ring derived from cyclohexenone (S21-S26) was obtained in this compound. The ability to inhibit both Gram-positive and Gram-negative microorganisms, including Staphylococcus aureus and E. coli was then examined. The composition was confirmed by several spectroscopic methods: IR, H1-NMR and C13-NMR. And using.