GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY

Abstract

This study involves the synthesis of thiazolidinone derivatives by reacting Schiff base derivatives with thioglycolic ‎‎acid. The reactions were conducted using both conventional and microwave methods and characterized using ‎determining melting points and purity, monitoring reaction progress and Rf ‎values using thin-layer chromatography ‎‎(TLC), and conducting infrared (FT-IR) spectroscopy, proton nuclear ‎magnetic resonance (1H-NMR) spectroscopy, ‎and quantitative elemental analysis (C.H.N.).‎ The biological activity of the synthesized compounds was evaluated by ‎examining their effects on the growth of four types of antibiotic-resistant bacterial isolates: two Gram-negative ‎strains (Escherichia et al.) and two Gram-positive strains (Staphylococcus aureus and Staphylococcus epidermidis). ‎The standard antibiotic Ampicillin was used as a control sample. The synthesized compounds exhibited good ‎inhibitory activity against the tested bacteria. Additionally, the laser activity of the synthesized compounds was ‎measured using a helium-neon laser (visible laser). The compounds were irradiated for four different periods (15, 30, ‎‎45, and 60) seconds, and their physical properties were re-examined to observe any changes resulting from the laser ‎irradiation.‎