ROLE OF EPIGENETIC FACTORS IN ACUTE LEUKEMIA

Abstract

The article examines historical aspects of epigenetics as an independent branch of biology, as well as issues of post-translational modifications of histones as epigenetic events. The work provides an overview of the main provisions of epigenetics in current articles and abstracts: DNA methylation, acetylation, phosphorylation and sumoylation of histones in the processes of oncological diseases. To date, the influence of so-called interfering RNA on epigenetic processes has attracted great interest. RNA interference (RNAi) can be used to identify epigenetic regulators for potential pharmacological targeting of tumor cells. The work examines the role of small molecules I-BET and JQ1 in the antitumor response. The importance of BET proteins in oncohematological diseases is highlighted separately. Currently, DNA methyltransferase inhibitors (hypomethylating agents) and inhibitors are used in the treatment of some blood system tumors. Histone deacetylases, which represent a new direction - epigenetic therapy