Preparation and Characterization of Some 1,3-Oxazepane -7,4-Dione Derivatives and Evaluation of their Biological Activity

Abstract

This study included the preparation of chaff bases using terephthaldehyde as a nucleus, reacting them with amine substitutes, and then reacting the resulting compounds with succinic anhydride in the presence of dry benzene as a solvent to obtain a heptad ring derived from oxazepane, whose biological effectiveness was tested against two types of gram-positive and gram-negative bacteria. The structures were validated using physical measurements. From the melting point, color change, and product percentage spectroscopic analyses, including proton nuclear magnetic resonance and infrared spectroscopy, were employed.