The Role of Immunological Factors in the Pathogenesis of HIV Infection in Women of Reproductive Age with Genital Inflammatory Diseases

Abstract

To date, many viral and host factors have been identified that determine the rate of progression and outcome of the disease in infected individuals [1,7]. Cellular tropism, which determines the viral phenotype, and receptor interactions, which mediate the penetration of the virus into various cell types, are the main factors influencing the pathogenesis of HIV infection [2,4]. However, studies conducted over the past 25 years do not provide a holistic view of the mechanism by which these factors lead to a significant decrease in the number of CD4+ T cells and an increase in X4- and R5-tropic strains at the AIDS stage [6].