INVESTIGATION OF THE SKIN-RESORPTIVE EFFECT OF MANUFACTURED CHITOSAN

Authors

  • Baykulov Azim Kenjayevich Associate Professor, Department of Biological Chemistry Samarkand State Medical University, Samarkand, Uzbekistan
  • Savetov Karokul Tashanovich Associate Professor, Department of Biological Chemistry Samarkand State Medical University, Samarkand, Uzbekistan
  • Maxbuba Erkin qizi Assistant, Department of Biological Chemistry Samarkand State Medical University, Samarkand, Uzbekistan
  • Keldiyorova Shoxida Xusniddin qizi Assistant, Department of Biological Chemistry Samarkand State Medical University, Samarkand, Uzbekistan
  • Inoyativa Feruza Hydoyatovna Professor, Department of Medical and Biological Chemistry Tashkent Medical Academy, Tashkent, Uzbekistan

Keywords:

chitosan, sensitizing effect, resorptive effect, irritation, cumulation, toxicological properties

Abstract

The aim of the work: study of the skin-resorptive and sensitizing effects of various chitosan derivatives.

Material and methods. To study the skin-resorptive and allegnizing effects of chitosan sulfate and chitosan with furacilin according to the recommendations for the study of the toxicological properties of drugs.

Results. For the first time, a complex of preclinical experimental studies of various chitosan derivatives developed at the nstitute of Polymer Chemistry and Physics of the Academy of Sciences of the Republic of Uzbekistan was carried out. It was revealed that they do not have a resorptive and irritating effect on the skin and mucous membranes of the eyes, does not cause sensitization of the body of guinea pigs. The drugs do not have a cumulative effect and sensitizing effect.

Conclusions: 1) chitosan sulfate and chitosan preparations with furacilin do not have a skin-resorptive effect and a locally irritating effect; 2) chitosan sulfate and chitosan preparations with furacilin do not have an allergenic effect.

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Published

2022-05-17

How to Cite

Kenjayevich, B. A. ., Tashanovich, S. K. ., qizi, M. E. ., qizi, K. S. X. ., & Hydoyatovna, I. F. . (2022). INVESTIGATION OF THE SKIN-RESORPTIVE EFFECT OF MANUFACTURED CHITOSAN. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 2(5), 102–106. Retrieved from http://inovatus.es/index.php/ejmmp/article/view/829

Issue

Vol. 2 No. 5 (2022): EJMMP

Section

Articles

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