BIOCHEMICAL CHANGES IN AMNIOTIC FLUID AFTER MATERNAL COVID-19

Authors

  • Djabborov U. U. Department of Obstetrics and Gynecology, Tashkent Pediatric Medical Institute, Associate professor
  • Nozimova N. H Tashkent Pediatric Medical Institute
  • Narzullayeva M. H. Tashkent Pediatric Medical Institute

Keywords:

COVID-19, pregnancy, amniotic fluid, biochemical markers, phosphatidylcholine, sphingomyelin, fetal lung maturity, placental stress, neonatal outcomes

Abstract

The COVID-19 pandemic has profoundly affected maternal and fetal health, especially in pregnant women. This study examines specific and non-specific biochemical indicators in the amniotic fluid of pregnant women who contracted COVID-19. Despite increasing information, few studies examine the correlation between these markers and fetal development, especially regarding lung maturity and placental function. To address this disparity, we performed a biochemical examination of amniotic fluid obtained from 70 pregnant women categorized into three groups: those with healthy pregnancies and those with COVID-19 throughout the second and third trimesters. Metabolites including phosphatidylcholine, sphingomyelin, total protein, and alpha-amylase were quantified utilizing high-performance liquid chromatography and biochemical analyzers. The findings indicated markedly reduced levels of phosphatidylcholine, sphingomyelin, and protein markers in women with COVID-19 relative to the control group. These reductions signify fetal lung immaturity and possible impairments in placental and hepatic function. Increased alkaline phosphatase levels indicated potential cellular injury. These discoveries underscore the necessity for focused monitoring and interventions during pregnancies impacted by COVID-19 to reduce hazards to fetal development. This study highlights the significance of comprehending the biochemical milieu of amniotic fluid following COVID-19 and its ramifications for neonatal outcomes, facilitating enhanced maternal and fetal care measures in pandemic contexts.

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Published

2024-11-28

How to Cite

U. U., D., N. H, N., & M. H., N. (2024). BIOCHEMICAL CHANGES IN AMNIOTIC FLUID AFTER MATERNAL COVID-19. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(11), 688–693. Retrieved from http://inovatus.es/index.php/ejmmp/article/view/4606

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