COMPARISON OF THE EFFECT OF COLCHIPRIT-NEO WITH KNOWN CYTOSTATICS AND STUDY OF ITS EFFECT ON IMMUNITY

Authors

  • Enikeeva Z. M. Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan
  • Urazov N. E. Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan
  • Ibragimov Sh. N. Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan
  • Zalyalieva M. V. Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan

Keywords:

new drug colchiprit-neo, activity, immunomodulatory effect, influence on CFUs

Abstract

The oral toxicity of colchipritol was 33-97 times lower than that of parenteral colchipritol, as well as its higher activity on used tumor strains, which was close to 90% and higher than that of reference drugs. Colchiprite- neo, when administered orally, is a substance capable, along with high antitumor activity, of stimulating immunity at a therapeutic dose, which is explained by its ability to stimulate CFUs.

References

1. Aliyeva D.A., Yenikeeva Z.M., Mavlyanova Z.F. Method of correction of hemo- and immunodeficiency states by derivatives of Tropolone alkoloids with high induction of colony formation. Monograph, India, 2022, 86 pp, www.novateurpublication.com

2. Enikeeva Z.M., Ibragimov A.A. A new class of cytostatics with stimulation of colony-forming units on the spleen (CFUs). Monograph. Tashkent, from "Fan va texnologiya," 2016, 173c

3. Methodological Guidelines for Studying Antitumor Activity of Pharmacological Substances ./Compiled by E.M. Treshchalina, O.S. Zhukova, G.K. Gerasimova, N.V. Andronova, A.M. Garin in Book "Guidelines for experimental (preclinical) study of new pharmacological substances." Under the general ed. R.U. Khabriev. Moscow, 2005, pp. 637-682.

4. Till J.E., Mc Culloch E.A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells//Radiat. Res. -1961.- V.14. - No1. - P.213-222.

5. S. Shaxanova. 68P The effectiveness of treatment of ascites due to recurrence of platinum-refractory ovarian cancer using metronomic chemotherapy. ESMO Open, Volume 9, Supplement 5, June 2024, 103575

6. Vypova N.L 1, Nishanov D A. , Madaliev A. A., Ibragimov Sh. N, Enikeeva Z. M., Urozov N. E. Study of Toxicology of the Antitumor Drug Colchiprit-Neo (K-20) . Journal of Medical Genetics and Clinical Biology, 2024, Vol. 1, No. 11 Page 42-49

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Published

2024-11-27

How to Cite

Enikeeva Z. M., Urazov N. E., Ibragimov Sh. N., & Zalyalieva M. V. (2024). COMPARISON OF THE EFFECT OF COLCHIPRIT-NEO WITH KNOWN CYTOSTATICS AND STUDY OF ITS EFFECT ON IMMUNITY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(11), 678–681. Retrieved from http://inovatus.es/index.php/ejmmp/article/view/4600

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