DISORDER OF THROMBOPOIETIN SYNTHESIS AND SOME LINKS OF HEMOSTATIS IN HEPATITIS AND THEIR DIAGNOSIS
Keywords:
thrombopoietin, hemostatic system, platelet, liver, hepatitis, megakaryocytopoiesisAbstract
Thrombopoietin is a protein also known as megakaryocyte growth factor. Thrombopoietin is a glycoprotein hormone produced primarily by the liver and to a lesser extent by the kidneys and striated muscle that regulates platelet production by the bone marrow. Stimulates the production and differentiation of megakaryocytes, bone marrow cells. Megakaryocytopoiesis is a process of cellular development that leads to the production of platelets. In the liver, thrombopoietin is produced by parenchymal cells and sinusoidal endothelial cells; in the kidneys, by proximal convoluted tubule cells. In addition, thrombopoietin is produced by striated muscle cells and bone marrow stromal cells. When its synthesis is disrupted, thrombocytopenia is observed, which is one of the main factors in the development of the hemostasis system. This article discusses these issues and provides some diagnostic criteria.
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