ESTIMATION OF THE DEVELOPMENT OF THE CARDIOVASCULAR MANIFESTATIONS IN OSTEOARTHRITIS

Abstract

Osteoarthritis (OA), аtherosclerosis and coronary heart disease (СНD) share common pathophysiological mechanisms associated with systemic and chronic inflammation. At the same time, traditional risk factors, such as hypertension, elderly age, smoking, hypercholesterolemia, obesity and sex, cannot fully explain the mechanism for the accelerated development of atherosclerosis in patients with OA. Specific risk factors, such as its duration, glucocorticoid use, anti-doublestranded (native) DNA autoantibodies and antiphospholipid antibodies, create conditions for the accelerated development of atherosclerosis in this group of patients. Purpose of the study. To evaluate the frequency of traditional cardiovascular risk factors, clinical and subclinical manifestations of atherosclerosis in patients with OA. Material and methods. We examined 70 patients with a reliable diagnosis of OA (66 women and 4 men), cf. age 46 ± 10.8 years. Control group - 50 "conditionally" healthy volunteers without systemic rheumatic diseases, matched by sex and age. Results. The prevalence of traditional cardiovascular risk factors and TFR% were comparable in patients with OA and in the control group. The frequency of menopause was higher in patients with OA (p=0.005). IHD was diagnosed more often in patients with OA (13% vs. 2%, p<0.05). The mean triglyceride level in OA patients was significantly higher than in the control group (p<0.001). There was a tendency to increase TIM max. and the frequency of thickening of the IMT complex in patients with OA compared with the control group. Conclusion. Among OA patients, there was a higher prevalence of clinical and subclinical manifestations of atherosclerosis compared with the control group, with no significant differences in the incidence of major cardiovascular risk factors.