THE ROLE OF VITAMIN D IN THE PREVENTION OF OSTEOPOROSIS IN MENOPAUSAL WOMEN

Abstract

The analysis was based on 5 randomized controlled trials for hip fracture risk (n=9294) and 7 randomized controlled trials for non-vertebral fracture risk (n=9820). All studies used cholecalciferol. A daily vitamin D intake of 700 to 800 IU was found to reduce the risk of hip fracture by 26% (3 randomized controlled trials with 5572 subjects; hazard ratio - RR = 0.74; 95% confidence interval i - CI 0.61–0.88) and 23% compared with placebo or calcium for non-vertebral fractures (with 6098 subjects 5 randomized controlled trials; RR = 0.77; 95% CI, 0.68–0.87). Low-dose (400 IU) vitamin D (2 randomized controlled trials with 3,722 participants; RR for hip fracture, 1.15; 95% CI, 0.88 to 1.50; RR, 1.15% CI); 0.8–1.24) [8].