DEVELOPMENT OF INNOVATIVE ROD APPARATUS FOR TREATMENT OF LONG BONES OF THE LOWER LIMB IN MULTIPLE AND COMBINED INJURIES

Authors

  • Makhsudov F. M. Samarkand State Medical University
  • Khojanov I. Yu. Samarkand State Medical University

Keywords:

immunosuppression, polytrauma, immunorehabilitation, IL-1, IL-6

Abstract

In the world, according to WHO, “...every year 5.8 million people die from severe injuries, and the number of people who become severely disabled exceeds this figure by more than three times. The mortality rate for abdominal injuries in combination with traumatic brain injury is 72.3%, for thoracoabdominal injury - 47.3%, in combination with damage to the musculoskeletal system - 38%. Today, numerous scientific studies are being conducted to improve the diagnosis and treatment of patients with polytraumas. Methods for improving and using minimally invasive approaches and low-traumatic devices for external fixation are being studied, algorithms and markers are being developed to reduce the mortality rate and possible complications. Immunosuppression in trauma occurs despite systemic activation of the immune system. It can be represented by pathogenetically heterogeneous processes. Severe mechanical trauma is accompanied by long-lasting antigenemia; due to extensive soft tissue hematomas, traumatic toxicosis gradually increases, which leads to the development of early purulent complications. In this regard, the study of the immunology of trauma is an important direction in the study of TB, and deepening knowledge in this area will significantly improve the effectiveness of medical care for victims, providing the opportunity for earlier correction at the pathogenetic level.

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Published

2024-07-05

How to Cite

Makhsudov F. M., & Khojanov I. Yu. (2024). DEVELOPMENT OF INNOVATIVE ROD APPARATUS FOR TREATMENT OF LONG BONES OF THE LOWER LIMB IN MULTIPLE AND COMBINED INJURIES. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 8–24. Retrieved from http://inovatus.es/index.php/ejmmp/article/view/3625