Preparation, characterization, and evaluation of the biological activity of new 2,3-dihydroquinazoline-4-one derivatives

Abstract

This study included the preparation of a new six-ring derivative of hydroquinazoline by reacting one mole of Schiff bases with two moles of anthralic acid in the presence of triethylamine as a catalyst and dioxane as a solvent. Its biological effectiveness was tested against two types of Gram-positive and Gram-negative bacteria. The validity of the structures was confirmed using physical measurements. From the melting point, color change, and product percentage, spectroscopic measurements were used, such as infrared spectroscopy and nuclear magnetic resonance spectroscopy for the proton and carbon.