Comparative Assessment of Indicators Cytokine Status in Children with Juvenile Rheumatoid Arthritis

Abstract

This scientific article examines the immunological mechanisms of the pathogenesis of juvenile rheumatoid arthritis, the importance of cytokines such as IL-8, IL-17A and INFy in intercellular immune connections and in the development of the inflammatory process. An imbalance of cytokines leading to a cascade of disturbances in immunological reactivity subsequently contributes to the development of autoimmunization and chronicization of the pathological process in JRA. We studied changes in the production of cytokine levels depending on age, dividing JRA into seronegative and seropositive forms. As a result, it was revealed that the level of IL-8, IL-17A was increased in children aged 15-18 years and the highest rates were in the seropositive form (38.3±4.06 pg/ml and 41.25±5 .14 pg/ml, respectively). And the level of INFy was sharply reduced in both groups of examined children with JRA. Next, we conducted a correlation analysis, which showed significant connections between IL-17A and INFy. Based on the results obtained, a disease prognosis index was compiled.